Is the mattress protector hypoallergenic? April 06, 2022 19:27 Yes, the mattress protector is made of cotton terry, which is designed to be both easy care and hypo-allergenic. Related articles Will the mattress protector reduce the breathability of the mattress? Can I use a boxspring on top of the high rise platform foundation? Will your mattresses develop body impressions? How do I set up my mattress? How do I choose the correct loft for my pillow?