Is the mattress protector hypoallergenic? April 06, 2022 19:27 Yes, the mattress protector is made of cotton terry, which is designed to be both easy care and hypo-allergenic. Related articles Will your mattresses develop body impressions? Can I use a boxspring on top of the high rise platform foundation? Will the mattress protector reduce the breathability of the mattress? How does the 120 Night Trial work? How do I set up my mattress?