Is the mattress protector hypoallergenic? April 06, 2022 19:27 Yes, the mattress protector is made of cotton terry, which is designed to be both easy care and hypo-allergenic. Related articles How long can I keep my mattress in the box? Do I need a mattress protector? What is the size and weight of the mattress box? How long does it take to break in my mattress? Is the mattress protector a full encasement?